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Ethyl-L-NIO (hydrochloride)

Cayman Chemical Item Number 10012088

L-N⁵-(1-Iminobutyl)ornithine hydrochloride (CAS 150403-97-7)

Ethyl-L-NIO (hydrochloride) (CAS 150403-97-7)

See more	Inhibitors (493) Neuroscience (654) Nitric Oxide (101)

Description

Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The K_i values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.¹ However when evaluating the K_i/K_m ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (K_i/K_m = 3.79, 5, and 0.96 µM, respectively).¹ Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O₂.¹

1 Babu, B.R., and Griffith, O.W. N⁵-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).

Synonyms	L-N5-(1-Iminobutyl)ornithine hydrochloride
Formal Name	N5-(1-iminobutyl)-L-ornithine, monohydrochloride
CAS Number	150403-97-7
Molecular Formula	C₉H₁₉N₃O₂ · HCl
Formula Weight	237.7
Formulation	A crystalline solid
Purity	≥95%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCC(=N)NCCC[C@H](N)C(=O)OCl

Background Reading

Babu, B.R., and Griffith, O.W. N⁵-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).

Size	Price	Quantity	Subtotal
5 mg	$43.00		$0.00
10 mg	$82.00		$0.00
50 mg	$344.00		$0.00
100 mg	$602.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

L-NIL (hydrochloride)

Methyl-L-NIO (hydrochloride)

Propenyl-L-NIO (hydrochloride) Exclusive

Vinyl-L-NIO (hydrochloride)

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