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CAY10583 Exclusive

Cayman Chemical Item Number 10012424

(CAS 862891-27-8)

CAY10583 (CAS 862891-27-8)

See more	Receptor Agonist (48) Atherosclerosis (323) Immunology (181) Inflammation (383)

Description

Leukotriene B₄ (LTB₄) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis. Two G protein-coupled receptors, BLT₁ and BLT₂ mediate the actions of LTB₄. CAY10583 is a potent, selective full agonist for BLT₂ with an EC₅₀ value of 20 nM.¹ It does not displace [³H]-LTB₄ binding to BLT₁ at concentrations >1 µM and activates BLT₂ at significantly lower concentrations than LTB₄ (EC₅₀ = 170 nM).¹ CAY10583 dose dependently increases intracellular calcium stores and induces ERK phosphorylation in Chinese hamster ovary (CHO) cells expressing BLT₂ with no effect on CHO cells expressing BLT₁.¹

1 Iizuka, Y., Yokomizo, T., Terawaki, K., et al. Characterization of a mouse second leukotriene B₄ receptor, mBLT2. BLT₂-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem 280(26) 24816-24823 (2005).

Formal Name	4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid
CAS Number	862891-27-8
Molecular Formula	C₂₅H₂₅NO₃
Formula Weight	387.5
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC(=O)N(Cc1ccc(cc1)c1ccccc1C(=O)O)c1ccccc1

Background Reading

Iizuka, Y., Yokomizo, T., Terawaki, K., et al. Characterization of a mouse second leukotriene B₄ receptor, mBLT2. BLT₂-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem 280(26) 24816-24823 (2005).

Size	Price	Quantity	Subtotal
5 mg	$46.00		$0.00
10 mg	$87.00		$0.00
25 mg	$207.00		$0.00
50 mg	$368.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

BLT₂ Receptor Polyclonal Antibody

Leukotriene B₄

LY255283

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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