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CG 4305

Cayman Chemical Item Number 10012447

CG 4305

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Description

Prostacyclin (PGI2) is a cyclooxygenase metabolite with antithrombotic properties found in vascular endothelial cells. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. CG 4305 is a stable carbacyclic analog of PGI2 that inhibits ADP-induced platelet aggregation 25% at a concentration of 50 nM.1 Doses of 10 mg/kg (oral) or 1 mg/kg (intraduodenal) have been shown to prevent rabbit carotid artery thrombosis.

1 Maurin, N. Influence on platelet activity and red cell fluidity of epoprostenol and two stable prostacyclin analogues in vitro. Arzneim -Forsch /Drug Res 36(8) 1180-1183 (1986).

Formal Name 3-​[(E)-​[(3aR,​4S,​5S,​6aR)-​4-​[(1E,​3R)-​3-​cyclohexyl-​3-​hydroxy-​1-​propen-​1-​yl]hexahydro-​5-​hydroxy-​2(1H)-​pentalenylidene]methyl]-​benzoic acid
Molecular Formula C25H32O4
Formula Weight 396.5
Formulation A solution in methyl acetate
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1CC2C\C(=C/c3cccc(c3)​C(=O)​O)​\CC2[C@H]​1\C=C\C(O)​C1CCCCC1

Background Reading

Maurin, N. Influence on platelet activity and red cell fluidity of epoprostenol and two stable prostacyclin analogues in vitro. Arzneim -Forsch /Drug Res 36(8) 1180-1183 (1986).
Size Price Quantity Subtotal
100 µg $82.00 $0.00
500 µg $369.00 $0.00
1 mg $656.00 $0.00
5 mg $2,870.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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