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Resolvin D1 Exclusive

Cayman Chemical Item Number 10012554

RvD1; 17(S)-Resolvin D1 (CAS 872993-05-0)

Resolvin D1 (CAS 872993-05-0)

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Description

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.1 A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.3 Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.4 RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.4

1 Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).

2 Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).

3 Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. J Exp Med 196(8) 1025-1037 (2002).

4 Sun, Y., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem 282(13) 9323-9334 (2007).

Synonyms
  • RvD1
  • 17(S)-Resolvin D1
Formal Name 7S,​8R,​17S-​trihydroxy-​4Z,​9E,​11E,​13Z,​15E,​19Z-​docosahexaenoic acid
CAS Number 872993-05-0
Molecular Formula C22H32O5
Formula Weight 376.5
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C[C@H]​(O)​/C=C/C=C/C=C\C=C/[C@@H]​(O)​[C@@H]​(O)​C/C=C\CCC(=O)​O

Background Reading

Sun, Y., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem 282(13) 9323-9334 (2007).

Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. J Exp Med 196(8) 1025-1037 (2002).

Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).

Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).

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Size Price Quantity Subtotal
10 µg $123.00 $0.00
25 µg $292.00 $0.00
50 µg $554.00 $0.00
100 µg $984.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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