Hydrogen sulfide (H2S) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium hydrogen sulfide is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration1, reduces airway inflammation2, and protects neurites,3 heart,4 and intestine5 from chemical or ischemic-reperfusion damage.
1
Dal-Secco, D., Cunha, T.M., Freitas, A., et al. Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: Role of ATP-sensitive potassium channels. J Immunol1814287-4298(2008).
2
Chen, Y., Wu, R., Geng, B., et al. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. Cytokine45117-123(2009).
3
Hu, L., Lu, M., Wu, Z., et al. Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function. Mol Pharmacol75(1)27-34(2009).
4
Yong, Q.C., Lee, S.W., Foo, C.S., et al. Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning. Am J Physiol Heart Circ Physiol295H1330-H1340(2008).
5
Liu, H., Bai, X., Shi, S., et al. Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. J Pharm Pharmacol61207-212(2009).
Synonyms
Sodium Hydrosulfide
NSC 158264
NaHS
Formal Name
sodium sulfide, hydrate
CAS Number
207683-19-0
Molecular Formula
HNaS · XH2O
Formula Weight
56.1
Formulation
A crystalline solid
Purity
≥65%
Stability
2 years
Storage
Room temperature
Shipping
Room temperature
in continental US; may vary elsewhere
SMILES
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[Na]S.O
Background Reading
Chen, Y., Wu, R., Geng, B., et al. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. Cytokine45117-123(2009).
Hu, L., Lu, M., Wu, Z., et al. Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function. Mol Pharmacol75(1)27-34(2009).
Yong, Q.C., Lee, S.W., Foo, C.S., et al. Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning. Am J Physiol Heart Circ Physiol295H1330-H1340(2008).
Liu, H., Bai, X., Shi, S., et al. Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. J Pharm Pharmacol61207-212(2009).
Dal-Secco, D., Cunha, T.M., Freitas, A., et al. Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: Role of ATP-sensitive potassium channels. J Immunol1814287-4298(2008).