Myricetin is a flavonoid compound found in many fruits and vegetables, including red wine, that acts as a powerful antioxidant.1 Myricetin inhibits TBARS formation with an IC50 value of 6.34 and at 20 µM, blocks oxLDL uptake by U937-derived macrophages, reducing CD36 expression.2 Myricetin demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit the neoplastic transformation of murine JB6 P+ cells and inhibiting MEK1 kinase activity.3,4
1
Bennett, C.J., Caldwell, S.T., McPhail, D.B., et al. Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorg Med Chem122079-2098(2004).
2
Lian, T., Wang, L., Lo, Y., et al. Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. Biochim Biophys Acta1781601-609(2008).
3
Kumamoto, T., Fujii, M., and Hou, D. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett27517-26(2009).
4
Lee, K.W., Kang, N.J., Rogozin, E.A., et al. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis28(9)1918-1927(2007).
Lee, K.W., Kang, N.J., Rogozin, E.A., et al. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis28(9)1918-1927(2007).
Kumamoto, T., Fujii, M., and Hou, D. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett27517-26(2009).
Lian, T., Wang, L., Lo, Y., et al. Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. Biochim Biophys Acta1781601-609(2008).
Bennett, C.J., Caldwell, S.T., McPhail, D.B., et al. Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorg Med Chem122079-2098(2004).