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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Myricetin

Cayman Chemical Item Number 10012600

NSC 407290; Cannabiscetin (CAS 529-44-2)

Myricetin (CAS 529-44-2)

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Description

Myricetin is a flavonoid compound found in many fruits and vegetables, including red wine, that acts as a powerful antioxidant.1 Myricetin inhibits TBARS formation with an IC50 value of 6.34 and at 20 µM, blocks oxLDL uptake by U937-derived macrophages, reducing CD36 expression.2 Myricetin demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit the neoplastic transformation of murine JB6 P+ cells and inhibiting MEK1 kinase activity.3,4

1 Bennett, C.J., Caldwell, S.T., McPhail, D.B., et al. Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorg Med Chem 12 2079-2098 (2004).

2 Lian, T., Wang, L., Lo, Y., et al. Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. Biochim Biophys Acta 1781 601-609 (2008).

3 Kumamoto, T., Fujii, M., and Hou, D. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett 275 17-26 (2009).

4 Lee, K.W., Kang, N.J., Rogozin, E.A., et al. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis 28(9) 1918-1927 (2007).

Synonyms
  • NSC 407290
  • Cannabiscetin
Formal Name 3,​5,​7-​trihydroxy-​2-​(3,​4,​5-​trihydroxyphenyl)-​4H-​1-​benzopyran-​4-​one
CAS Number 529-44-2
Molecular Formula C15H10O8
Formula Weight 318.2
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1cc(O)​c2c(c1)​oc(c1cc(O)​c(O)​c(O)​c1)​c(O)​c2=O

Background Reading

Lee, K.W., Kang, N.J., Rogozin, E.A., et al. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis 28(9) 1918-1927 (2007).

Kumamoto, T., Fujii, M., and Hou, D. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett 275 17-26 (2009).

Lian, T., Wang, L., Lo, Y., et al. Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. Biochim Biophys Acta 1781 601-609 (2008).

Bennett, C.J., Caldwell, S.T., McPhail, D.B., et al. Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation. Bioorg Med Chem 12 2079-2098 (2004).

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Myricetin is available in the following screening library:

Size Price Quantity Subtotal
10 mg $21.00 $0.00
25 mg $47.00 $0.00
50 mg $84.00 $0.00
100 mg $126.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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