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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(S)-MG132

Cayman Chemical Item Number 10012628

Z-Leu-Leu-Leu-CHO (CAS 133407-82-6)

(S)-MG132 (CAS 133407-82-6)

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Description

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression.1,2 (S)-MG132 is a potent, reversible and cell permeable proteasome inhibitor that inhibits cell growth in B16 and IPC227F cells with IC50 values of 42 and 77 nM, respectively.3 (S)-MG132 at 10 µM inhibits NF-κB activation, sensitizing a variety of carcinoma cell lines to apoptosis.4

1 Lee, D.H., and Goldberg, A.L. Proteasome inhibitors: Valuable new tools for cell biologists. Trends Cell Biol 8 397-403 (1998).

2 Elliott, P.J., Zollner, T.M., and Boehncke, W. Proteasome inhibition: A new anti-inflammatory strategy. J Mol Med 81 235-245 (2003).

3 Vivier, M., Rapp, M., Papon, J., et al. Synthesis, radiosynthesis, and biological evaluation of new proteasome inhibitors in a tumor targeting approach. J Med Chem 51(4) 1043-1047 (2008).

4 Arlt, A., Vorndamm, J., Breitenbroich, M., et al. Inhibition of NF-kB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene 20 859-868 (2001).

Synonyms
  • Z-Leu-Leu-Leu-CHO
Formal Name N-​[(phenylmethoxy)carbonyl]-​L-​leucyl-​N-​[(1S)-​1-​formyl-​3-​methylbutyl]-​L-​leucinamide
CAS Number 133407-82-6
Molecular Formula C26H41N3O5
Formula Weight 475.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C[C@H]​(CC(C)​C)​NC(=O)​[C@@H]​(CC(C)​C)​NC(=O)​[C@H]​(CC(C)​C)​NC(=O)​OCc1ccccc1

Background Reading

Elliott, P.J., Zollner, T.M., and Boehncke, W. Proteasome inhibition: A new anti-inflammatory strategy. J Mol Med 81 235-245 (2003).

Vivier, M., Rapp, M., Papon, J., et al. Synthesis, radiosynthesis, and biological evaluation of new proteasome inhibitors in a tumor targeting approach. J Med Chem 51(4) 1043-1047 (2008).

Lee, D.H., and Goldberg, A.L. Proteasome inhibitors: Valuable new tools for cell biologists. Trends Cell Biol 8 397-403 (1998).

Arlt, A., Vorndamm, J., Breitenbroich, M., et al. Inhibition of NF-kB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene 20 859-868 (2001).

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Size Price Quantity Subtotal
1 mg $12.00 $0.00
5 mg $54.00 $0.00
10 mg $96.00 $0.00
50 mg $420.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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