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Ki16425

Cayman Chemical Item Number 10012659

(CAS 355025-24-0)

Ki16425 (CAS 355025-24-0)

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Description

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5).1 Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells.2 Ki1642, at 10 µM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.3

1 Choi, J.W., Lee, C., and Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: An update. Biochim Biophys Acta 1781 531-539 (2008).

2 Ohta, H., Sato, K., Murata, N., et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol 64(4) 994-1005 (2003).

3 Yamada, T., Sato, K., Komachi, M., et al. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA. J Biol Chem 279(8) 6595-6605 (2004).

Formal Name 3-​[[[4-​[4-​[[[1-​(2-​chlorophenyl)ethoxy]carbonyl]amino]-​3-​methyl-​5-​isoxazoly]phenyl]methyl]thio]-​propanoic acid
CAS Number 355025-24-0
Molecular Formula C23H23ClN2O5S
Formula Weight 475.0
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​CCSCc1ccc(cc1)​c1onc(C)​c1NC(=O)​OC(C)​c1ccccc1Cl

Background Reading

Ohta, H., Sato, K., Murata, N., et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol 64(4) 994-1005 (2003).

Choi, J.W., Lee, C., and Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: An update. Biochim Biophys Acta 1781 531-539 (2008).

Yamada, T., Sato, K., Komachi, M., et al. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA. J Biol Chem 279(8) 6595-6605 (2004).
Size Price Quantity Subtotal
1 mg $26.00 $0.00
5 mg $117.00 $0.00
10 mg $208.00 $0.00
100 mg $1,560.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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