See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10607 Exclusive

Cayman Chemical Item Number 10012694

Benzisoxazole Hsp90 Inhibitor; BHI (CAS 1012788-65-6)

CAY10607 (CAS 1012788-65-6)

See more

Description

Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. CAY10607 binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM).1 In addition, CAY10607 inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.1

1 Gopalsamy, A., Shi, M., Golas, J., et al. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J Med Chem 51 373-375 (2008).

Synonyms
  • Benzisoxazole Hsp90 Inhibitor
  • BHI
Formal Name 4-​chloro-​6-​[5-​[[2-​(4-​morpholinyl)ethyl]amino]-​1,​2-​benzisoxazol-​3-​yl]-​1,​3-​benzenediol
CAS Number 1012788-65-6
Molecular Formula C19H20ClN3O4
Formula Weight 389.8
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
Oc1cc(O)​c(cc1Cl)​c1noc2ccc(NCCN3CCOCC3)​cc12

Background Reading

Gopalsamy, A., Shi, M., Golas, J., et al. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. J Med Chem 51 373-375 (2008).
Size Price Quantity Subtotal
1 mg $98.00 $0.00
5 mg $441.00 $0.00
10 mg $784.00 $0.00
25 mg $1,715.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Hsp90 Monoclonal Antibody (Clone AC-16)
Hsp90 Monoclonal Antibody Complex (Clone 8D3)
Hsp90 (salmonid) Polyclonal Antibody
Hsp90α Monoclonal Antibody (Clone D7α)
Hsp90α Monoclonal Antibody (Clone K41009)
Hsp90α/β Monoclonal Antibody (Clone K41220A)
Hsp90β Monoclonal Antibody (Clone H90-10)
Hsp90β Monoclonal Antibody (Clone K3701)
VER-49009 Exclusive
Show all 9 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?