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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

JMV3002 Exclusive

Cayman Chemical Item Number 10012699

(CAS 925239-03-8)

JMV3002 (CAS 925239-03-8)

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Description

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro.1 At 80 µg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats.1 JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 µg/kg.1

1 Moulin, A., Demange, L., Ryan, J., et al. New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem 51 689-693 (2008).

Formal Name N-​[(1R)-​1-​[4-​[(2,​4-​dimethoxyphenyl)methyl]-​5-​(2-​phenyylethyl)-​4H-​1,​2,​4-​triazol-​3-​yl]-​2-​(1H-​indol-​3-​yl)ethyl]-​2-​pyridinecarboxamide
CAS Number 925239-03-8
Molecular Formula C35H34N6O3
Formula Weight 586.7
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(Cn2c(CCc3ccccc3)​nnc2C(NC(=O)​c2ccccn2)​Cc2c[nH]​c3ccccc23)​c(OC)​c1

Background Reading

Moulin, A., Demange, L., Ryan, J., et al. New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem 51 689-693 (2008).
Size Price Quantity Subtotal
100 µg $43.00 $0.00
500 µg $194.00 $0.00
1 mg $344.00 $0.00
5 mg $1,505.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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