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A-922500

Cayman Chemical Item Number 10012708

(1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid (CAS 959122-11-3)

A-922500 (CAS 959122-11-3)

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Description

Diacylglycerol acyltransferases (DGATs) catalyze the final step in triglyceride synthesis. DGAT-1 deficient mice demonstrate a phenotype that is protective against the development of diet-induced obesity (DIO) or insulin resistance, implicating the actions of this enzyme in the development of such metabolic disorders. A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively.1 When administered at 3 mg/kg to DIO mice, A-922500 conferred significant weight loss within seven days without affecting food intake and significantly reduced plasma and liver triglycerides with chronic dosing.1 A-922500 does not inhibit DGAT-2, ACAT-1, or ACAT-2.1

1 Zhao, G., Souers, A.J., Voorbach, M., et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem 51 380-383 (2008).

Synonyms
  • (1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)-cyclopentanecarboxylic acid
Formal Name 2R-​[[4’-​[[(phenylamino)carbonyl]amino][1R,​1’-​biphenyl]-​4-​yl-​carbonyl]-​cyclopentanecarboxylic acid
CAS Number 959122-11-3
Molecular Formula C26H24N2O4
Formula Weight 428.5
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(NC1=CC=C(C2=CC=C(C([C@@H]​3CCC[C@H]​3C(O)​=O)​=O)​C=C2)​C=C1)​NC4=CC=CC=C4
Size Price Quantity Subtotal
1 mg $30.00 $0.00
5 mg $135.00 $0.00
10 mg $240.00 $0.00
25 mg $525.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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