Prostaglandin A1-biotin

Prostaglandin A₁-biotin

Cayman Chemical Item Number 10013

PGA₁-biotin

Description

PGA₁ is one of the cyclopentenone prostaglandins, which have well documented antimitotic and antiproliferative effects.^1,2 The activity of the compounds in this class, which includes prostaglandins in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G-protein coupled receptor) pathways. PGA₁-biotin is an affinity probe which allows PGA₁ to be detected through an interaction with the biotin ligand. PGA₁-biotin was designed to allow PGA₁ to be detected in complexes with nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone prostaglandins.

1 Bregman, M.D., and Meyskens, F.L. Inhibition of human malignant melanoma colony-forming cells in vitro by prostaglandin A₁. Cancer Res 43 1642-1645 (1983).

2 Lacal, P.M., Amici, C., Bonmassar, E., et al. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. J Pharmacol Exp Ther 271 1096-1102 (1994).

Synonyms

PGA1-biotin

Formal Name

N-9-oxo-15S-hydroxy-prosta-10,13E-dien-1-oyl-N'-biotinoyl-1,6-diaminopentane

Molecular Formula

C₃₅H₅₈N₄O₅S

Formula Weight

646.9

Formulation

A solution in ethanol

Purity

>95%

Stability

1 year

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

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O=C1[C@H](CCCCCCC(NCCCCCNC(CCCC[C@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1

Background Reading

Lacal, P.M., Amici, C., Bonmassar, E., et al. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. J Pharmacol Exp Ther 271 1096-1102 (1994).

Bregman, M.D., and Meyskens, F.L. Inhibition of human malignant melanoma colony-forming cells in vitro by prostaglandin A₁. Cancer Res 43 1642-1645 (1983).

Size

Price

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Subtotal

100 µg 
$26.00

$0.00

500 µg 
$117.00

$0.00

1 mg 
$208.00

$0.00

5 mg 
$910.00

$0.00

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Prostaglandin A₁-biotin