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N-Ac-Asp-Glu-Val-Asp-CHO

Cayman Chemical Item Number 10017

Ac-DEVD-CHO (CAS 184179-08-6)

N-Ac-Asp-Glu-Val-Asp-CHO (CAS 184179-08-6)

See more	Inhibitors (493) Apoptosis (183)

Description

N-Ac-Asp-Glu-Val-Asp-CHO (Ac-DEVD-CHO) is a potent and selective inhibitor of Caspase-3.¹ Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.²

1 Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. J Biol Chem 272 9677-9682 (1997).

2 Nicholson, D.W., Ali, A., Thornberry, N.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376 37-43 (1995).

Synonyms	Ac-DEVD-CHO
Formal Name	N-acetyl-L-α-aspartyl-L-α-glutamyl-N-(2-carboxyl-1-formylethyl)-L-valinamide
CAS Number	184179-08-6
Molecular Formula	C₂₀H₃₀N₄O₁₁
Formula Weight	502.5
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C)C(C)C

Background Reading

Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. J Biol Chem 272 9677-9682 (1997).

Nicholson, D.W., Ali, A., Thornberry, N.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376 37-43 (1995).

Size	Price	Quantity	Subtotal
500 µg	$37.00		$0.00
1 mg	$70.00		$0.00
5 mg	$296.00		$0.00
10 mg	$518.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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