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DDMS

Cayman Chemical Item Number 10018

Dibromo-dodecenyl-methylsulfimide (CAS 206052-03-1)

DDMS (CAS 206052-03-1)

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Description

Biosynthesis of 20-HETE from arachidonic acid by the cytochrome P450 4A (CYP450 4A) isoforms is an important component of vascular homeostasis, especially in renal circulation.1 DDMS is a mechanism-based, irreversible inhibitor that has about 10-fold selectivity for the CYP4A2 enzyme which predominantly synthesizes 20-HETE in the mammalian kidney. DDMS administration in whole anesthetized rats (10 mg/kg) largely ablates the hypotension and vasodilation induced by nitric oxide donors such as NONOates.2

1 Lasker, J.M., Chen, W.B., Wolf, I., et al. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11. J Biol Chem 275(6) 4118-4126 (2000).

2 Alonso-Galicia, M., Drummond, H.A., Reddy, K.K., et al. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension 29 320-325 (1997).

Synonyms
  • Dibromo-dodecenyl-methylsulfimide
Formal Name 12,​12-​dibromo-​N-​(methylsulfonyl)-​11-​dodecenamide
CAS Number 206052-03-1
Molecular Formula C13H23Br2NO3S
Formula Weight 433.2
Formulation A crystalline solid
Purity >98%
λmax 203 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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BrC(=CCCCCCCCCCC(=O)​NS(=O)​(=O)​C)​Br

Background Reading

Alonso-Galicia, M., Drummond, H.A., Reddy, K.K., et al. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension 29 320-325 (1997).

Lasker, J.M., Chen, W.B., Wolf, I., et al. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11. J Biol Chem 275(6) 4118-4126 (2000).

DDMS is available in the following screening library:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
50 mg $1,785.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

CAY10434
CAY10462
β-Gal-NONOate

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