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DDMS

Cayman Chemical Item Number 10018

Dibromo-dodecenyl-methylsulfimide (CAS 206052-03-1)

DDMS (CAS 206052-03-1)

See more	Eicosanoids (216) Fatty Acids (267) Lipid Mediators (47) Cytochrome P450 (88) Hypertension (90)

Description

Biosynthesis of 20-HETE from arachidonic acid by the cytochrome P450 4A (CYP450 4A) isoforms is an important component of vascular homeostasis, especially in renal circulation.¹ DDMS is a mechanism-based, irreversible inhibitor that has about 10-fold selectivity for the CYP4A2 enzyme which predominantly synthesizes 20-HETE in the mammalian kidney. DDMS administration in whole anesthetized rats (10 mg/kg) largely ablates the hypotension and vasodilation induced by nitric oxide donors such as NONOates.²

1 Lasker, J.M., Chen, W.B., Wolf, I., et al. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11. J Biol Chem 275(6) 4118-4126 (2000).

2 Alonso-Galicia, M., Drummond, H.A., Reddy, K.K., et al. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension 29 320-325 (1997).

Synonyms	Dibromo-dodecenyl-methylsulfimide
Formal Name	12,12-dibromo-N-(methylsulfonyl)-11-dodecenamide
CAS Number	206052-03-1
Molecular Formula	C₁₃H₂₃Br₂NO₃S
Formula Weight	433.2
Formulation	A crystalline solid
Purity	>98%
λ_max	203 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard BrC(=CCCCCCCCCCC(=O)NS(=O)(=O)C)Br

Background Reading

Lasker, J.M., Chen, W.B., Wolf, I., et al. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11. J Biol Chem 275(6) 4118-4126 (2000).

Alonso-Galicia, M., Drummond, H.A., Reddy, K.K., et al. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension 29 320-325 (1997).

DDMS is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$51.00		$0.00
5 mg	$230.00		$0.00
10 mg	$408.00		$0.00
50 mg	$1,785.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

CAY10434

CAY10462

β-Gal-NONOate

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