Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

F16

Cayman Chemical Item Number 10022

(CAS 36098-33-6)

F16 (CAS 36098-33-6)

See more	Fluorescence (90) Apoptosis (183) Cancer (606)

Description

F16 is a small, cationic, lipophilic molecule which binds preferentially to mitochondrial membranes and disrupts their function.¹ F16 was discovered in high throughput screens for tumor inhibitors, where it was found to induce apoptosis in HER-1/EGFR-expressing breast carcinoma cell lines. In addition to being a potential antitumor agent, F16 is an easily visualized fluorescent molecule which can also be used to visualize mitochondria under confocal microscopy. The mechanism of apoptosis induction by F16 is believed to be through disruption of the mitochondrial transmembrane potential.¹

1 Fantin, V.R., Berardi, M.J., Scorrano, L., et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2 29-42 (2002).

Formal Name	4-[(1E)-2-(1H-indol-3-yl)ethenyl]-1-methyl-pyridinium iodide
CAS Number	36098-33-6
Molecular Formula	C₁₆H₁₅N₂ · I
Formula Weight	362.2
Formulation	A crystalline solid
Purity	≥98%
λ_max	443 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard C[n]1ccc(cc1)\C=C/c1c[nH]c2ccccc12

Background Reading

Fantin, V.R., Berardi, M.J., Scorrano, L., et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2 29-42 (2002).

F16 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$9.00		$0.00
5 mg	$41.00		$0.00
10 mg	$72.00		$0.00
50 mg	$315.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

PRIMA-1

Downloads

	Download Product Insert 85 Kb PDF
	Download Material Safety Data Sheet (MSDS) 71 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

F16