See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

N-(α-Linolenoyl) Tyrosine

Cayman Chemical Item Number 10032

NALT (CAS 259143-19-6)

N-(α-Linolenoyl) Tyrosine (CAS 259143-19-6)

See more

Description

Certain chronic neurologic disorders, such as Parkinson’s disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons.1 N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier.2 In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson’s therapeutic agent.2

1 Martin, J.B. Molecular basis of the neurodegenerative disorders. N Engl J Med 340 1970-1980 (1999).

2 Yehuda, S. Possible anti-Parkinson properties of N-(α-linolenoyl) tyrosine: A new molecule. Pharmacol Biochem Behav 72 7-11 (2002).

Synonyms
  • NALT
Formal Name N-​(L-​tyrosine)-​9Z,​12Z,​15Z-​octadecatrienamide
CAS Number 259143-19-6
Molecular Formula C27H39NO4
Formula Weight 441.6
Formulation A solution in ethanol
Purity >98%
λmax 226, 278 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CC/C=C\C/C=C\C/C=C\CCCCCCCC(N([C@H]​(C(O)​=O)​CC1=CC=C(O)​C=C1)​[H]​)​=O

Background Reading

Yehuda, S. Possible anti-Parkinson properties of N-(α-linolenoyl) tyrosine: A new molecule. Pharmacol Biochem Behav 72 7-11 (2002).

Martin, J.B. Molecular basis of the neurodegenerative disorders. N Engl J Med 340 1970-1980 (1999).

N-(α-Linolenoyl) Tyrosine is available in the following screening libraries:

Size Price Quantity Subtotal
5 mg $57.00 $0.00
10 mg $108.00 $0.00
50 mg $456.00 $0.00
100 mg $798.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

9-Octadecenamide
Docosahexaenoic Acid
N-Arachidonoyl Dopamine
N-Oleoyl Dopamine
α-Linolenoyl Ethanolamide Exclusive
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?