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TMS

Cayman Chemical Item Number 10038

2,3',4,5'-Tetramethoxystilbene (CAS 24144-92-1)

TMS (CAS 24144-92-1)

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Description

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.1 It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.1 In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.2

1 Kim, S., Ko, H., Park, J.E., et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem 45 160-164 (2002).

2 Nam, K.A., Kim, S., Heo, Y.H., et al. Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch Pharm Res 24(5) 441-445 (2001).

Synonyms
  • 2,3',4,5'-Tetramethoxystilbene
Formal Name 1-​[(1E)-​2-​(3,​5-​dimethoxyphenyl)ethenyl]-​2,​4-​dimethoxy-​benzene
CAS Number 24144-92-1
Molecular Formula C18H20O4
Formula Weight 300.4
Formulation A crystalline solid
Purity >98%
λmax 302, 326 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COC1=CC(/C=C/C2=C(OC)​C=C(OC)​C=C2)​=CC(OC)​=C1

Background Reading

Nam, K.A., Kim, S., Heo, Y.H., et al. Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch Pharm Res 24(5) 441-445 (2001).

Kim, S., Ko, H., Park, J.E., et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem 45 160-164 (2002).

TMS is available in the following screening library:

Size Price Quantity Subtotal
1 mg $11.00 $0.00
5 mg $50.00 $0.00
10 mg $88.00 $0.00
50 mg $385.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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