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UCM707Cayman Chemical Item Number 10045 (CAS 390824-20-1) 
UCM707 (CAS 390824-20-1)
Description
Numerous analogs of arachidonoyl ethanolamide (AEA, anandamide)1 potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons.2 One of the more potent and selective reuptake inhibitors is UCM707, a 3-
1 Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992).
2
Deutsch, D.G., Glaser, S.T., Howell, J.M., et al. The cellular uptake of anandamide is coupled to its breakdown by fatty- 3 López-Rodriguez, M.L., Viso, A., Ortega-Gutiérrez, S., et al. Design, synthesis, and biological evaluation of new endocannabinoid transporter inhibitors. Eur J Med Chem 38 403-412 (2003). 4 de Lago, E., Fernandez-Ruiz, J., Ortega-Gutiérrez, S., et al. UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide. Eur J Pharmacol 449 99-103 (2002 Jun 20).
Background ReadingDevane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946-1949 (1992). Deutsch, D.G., Glaser, S.T., Howell, J.M., et al. The cellular uptake of anandamide is coupled to its breakdown by fatty- López-Rodriguez, M.L., Viso, A., Ortega-Gutiérrez, S., et al. Design, synthesis, and biological evaluation of new endocannabinoid transporter inhibitors. Eur J Med Chem 38 403-412 (2003). de Lago, E., Fernandez-Ruiz, J., Ortega-Gutiérrez, S., et al. UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide. Eur J Pharmacol 449 99-103 (2002 Jun 20). Show all 4 Hide all but first 3UCM707 is available in the following screening library: |
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