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URB597Cayman Chemical Item Number 10046 (CAS 546141-08-6) 
URB597 (CAS 546141-08-6)
Description
The enzyme fatty acid amide hydrolase (FAAH) is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.1 URB597 was recently synthesized and reported to be a potent and selective inhibitor of FAAH.2 URB597 inhibits FAAH with an IC50 of 4.6 nM in brain membranes and 0.5 nM in intact neurons. It has been demonstrated in FAAH(-
1
Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty- 2 Kathuria, S., Gaetani, S., Fegley, D., et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 1(9) 76-81 (2003). 3 Cravatt, B.F., Demarest, K., Patricelli, M.P., et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA 98(16) 9371-9376 (2001).
Background ReadingCravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty- Kathuria, S., Gaetani, S., Fegley, D., et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 1(9) 76-81 (2003). Cravatt, B.F., Demarest, K., Patricelli, M.P., et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA 98(16) 9371-9376 (2001). URB597 is available in the following screening library: |
This product is available in custom sizes and/or larger quantities. Please contact our Sales Department for a quote or to purchase. Pricing updated 2012-02-10. Prices are subject to change without notice. To ask for assistance with one of our products please contact a Technical Support Scientist. Warning This product is not for human or veterinary use. Related ProductsShow all 11 Hide all but first 3Downloads
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins. |
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