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8-iso Misoprostol Exclusive

Cayman Chemical Item Number 10047

8-iso Misoprostol

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Description

Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.1 Misoprostol has been used therapeutically for many years in humans for the treatment of gastric ulcer disease under the Searle tradename Cytotec.2 8-iso Misoprostol is one of several impurities which are possible in the production of bulk commercial preparations of misoprostol, and is somewhat difficult to distinguish from other impurities such as 11β-misoprostol.3 The pharmacology and EP receptor binding affinity for 8-iso misoprostol has not been published.

1 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

2 Collins, P.W. Misoprostol: Discovery, development, and clinical applications. Med Res Rev 10 149-172 (1990).

3 Iyer, R.R. Personal Communication. (2002).

Formal Name 9-​oxo-​11α,​16-​dihydroxy-​16-​methyl-​(8β)-​prost-​13E-​en-​1-​oic acid,​ methyl ester
Molecular Formula C22H38O5
Formula Weight 382.5
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC(C)​(O)​C/C=C/[C@H]​1C(O)​CC(=O)​[C@H]​1CCCCCCC(=O)​OC

Background Reading

Iyer, R.R. Personal Communication. (2002).

Collins, P.W. Misoprostol: Discovery, development, and clinical applications. Med Res Rev 10 149-172 (1990).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

8-iso Misoprostol is available in the following screening libraries:

Size Price Quantity Subtotal
250 µg $45.00 $0.00
500 µg $86.00 $0.00
1 mg $162.00 $0.00
5 mg $720.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

11β-Misoprostol
Misoprostol
Misoprostol (free acid)
Misoprostol (free acid)-d5
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