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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

16,16-dimethyl Prostaglandin A1

Cayman Chemical Item Number 10080

16,16-dimethyl PGA1 (CAS 41692-24-4)

16,16-dimethyl Prostaglandin A1 (CAS 41692-24-4)

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Description

16,16-dimethyl PGA1 is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 µg/ml and 4.6-7.3 µg/ml, respectively. The ID50 for T cells acutely infected with HIV-1 is 2.5 µg/ml.1

1 Hughes-Fulford, M., McGrath, M.S., Hanks, D., et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother 36 2253-2258 (1992).

Synonyms
  • 16,16-dimethyl PGA1
Formal Name 9-​oxo-​15R-​hydroxy-​16,​16-​dimethyl-​prosta-​10,​13E-​dien-​1-​oic acid
CAS Number 41692-24-4
Molecular Formula C22H36O4
Formula Weight 364.5
Formulation A solution in methyl acetate
Purity >99% deuterated product
λmax 216 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC(C)​(C)​C(O)​\C=C\[C@H]​1C=CC(=O)​C1CCCCCCC(=O)​O

Background Reading

Hughes-Fulford, M., McGrath, M.S., Hanks, D., et al. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother 36 2253-2258 (1992).

16,16-dimethyl Prostaglandin A1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $70.00 $0.00
5 mg $315.00 $0.00
10 mg $560.00 $0.00
50 mg $2,450.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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Prostaglandin A1 methyl ester Exclusive
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