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Adenosine Receptor A2A Blocking Peptide

Cayman Chemical Item Number 10092

A2AR

See more	Immunocytochemistry (146) Western Blot (557) Atherosclerosis (323) Neuroscience (654) Parkinson's Research (18) Vascular Disease (103)

Description

Antigen: human adenosine receptor a2A amino acids 213 – 220 · Adenosine Receptor A2A is a multi-pass membrane protein that is normally localized to the plasma membrane.¹ This receptor is part of the G-protein coupled receptor family that binds adenosine and keeps it in equilibrium inside and outside the cell. Along with establishing this equilibrium, A2AR serves multiple functions and antagonists of this receptor have been targeted for the treatment of Parkinson’s disease.^2,3 This protein is primarily found in the striatum, but can also be found in immune cells and other tissues as well.² A2AR is 412 amino acids long with an expected molecular weight of 45 kDa. The receptor also has multiple glycosylation sites that explain the higher band shift seen in western blotting.¹

1 Piersen, C.E., True, C.D., and Well, J.N. A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding. Mol Pharmacol 45(5) 861-870 (1994).

2 Fredholm, B.B., Chern, Y., Franco, R., et al. Aspects of the general biology of adenosine A2A signaling. Prog Neurobiol 83 263-276 (2007).

3 Ledent, C., Vaugeois, J., Schiffmann, S.N., et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388 674-678 (1997).

Synonyms	A2AR
Formulation	200 µg of peptide in 200 µl of TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Ledent, C., Vaugeois, J., Schiffmann, S.N., et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388 674-678 (1997).

Piersen, C.E., True, C.D., and Well, J.N. A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding. Mol Pharmacol 45(5) 861-870 (1994).

Fredholm, B.B., Chern, Y., Franco, R., et al. Aspects of the general biology of adenosine A2A signaling. Prog Neurobiol 83 263-276 (2007).

Robeva, A.S., Woodward, R.L., Jin, X., et al. Molecular characterization of recombinant human adenosine receptors. Drug Dev Res 39 243-252 (1996).

Rosin, D.L., Robeva, A., Woodward, R.L., et al. Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. J Comp Neurol 401 1631-186 (1998).

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Size	Price	Quantity	Subtotal
200 µg	$107.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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