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EA4

Cayman Chemical Item Number 10111

EA4

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Description

rPLA2 is a calcium-dependent cytosolic phospholipase A2 (cPLA2) initially isolated and characterized from bovine and human red blood cells (RBCs).1 It has a molecular mass of 42 kDa and biochemical properties similar to cPLA2 Type IV. EA4 is a quinone derivative that inhibits rPLA2 with a Ki of 130 µM. It inhibits the ionophore-induced arachidonic acid release from human and bovine RBCs, indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs.1 EA4 causes significant time- and concentration-dependent induction of cytochrome P450 1A1 (CYP1A1) mRNA and protein in murine hepatoma Hepa-1c1c7 cells.2 EA4 also modulates CYP1A1 and CYP1B1 expression in other cell lines such as MCF-7, Hep-G2, and HL-60.2

1 Shin, H.S., Chin, M., Kim, J.S., et al. Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells. J Biol Chem 277 21086-21094 (2002).

2 Chun, Y.J., Lee, B.Y., Yang, S.A., et al. Induction of cytochrome P450 1A1 gene expression by a vitamin K3 analog in mouse hepatoma Hepa-1c1c7 cells. Mol Cells 12 190-196 (2001).

Formal Name 7-​chloro-​6-​[4-​(diethylamino)phenyl]-​5,​8-​quinolinedione
Molecular Formula C19H17ClN2O2
Formula Weight 340.8
Formulation A crystalline solid
Purity ≥95%
λmax 202, 242, 280, 600 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCN(CC)​c1ccc(cc1)​C1=C(Cl)​C(=O)​c2ncccc2C1=O

Background Reading

Shin, H.S., Chin, M., Kim, J.S., et al. Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells. J Biol Chem 277 21086-21094 (2002).

Chun, Y.J., Lee, B.Y., Yang, S.A., et al. Induction of cytochrome P450 1A1 gene expression by a vitamin K3 analog in mouse hepatoma Hepa-1c1c7 cells. Mol Cells 12 190-196 (2001).

EA4 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $73.00 $0.00
10 mg $139.00 $0.00
50 mg $584.00 $0.00
100 mg $1,022.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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