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CP 24,879 (hydrochloride)

Cayman Chemical Item Number 10120

p-(Isopentyloxy)-aniline (CAS 10141-51-2)

CP 24,879 (hydrochloride) (CAS 10141-51-2)

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Description

Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6 desaturase.1 Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.2

1 Obukowicz, M.G., Raz, A., Pyla, P.D., et al. Identification and characterization of a novel Δ6/Δ5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol 55 1045-1058 (1998).

2 Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J 365 489-496 (2002).

Synonyms
  • p-(Isopentyloxy)-aniline
Formal Name 4-​(3-​methylbutoxy)-​benzenamine,​ monohydrochloride
CAS Number 10141-51-2
Molecular Formula C11H17NO · HCl
Formula Weight 215.8
Formulation A crystalline solid
Purity ≥98%
λmax 275 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC1=CC=C(C=C1)​OCCC(C)​C.Cl

Background Reading

Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J 365 489-496 (2002).

Obukowicz, M.G., Raz, A., Pyla, P.D., et al. Identification and characterization of a novel Δ6/Δ5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol 55 1045-1058 (1998).

CP 24,879 (hydrochloride) is available in the following screening library:

Size Price Quantity Subtotal
1 mg $24.00 $0.00
5 mg $108.00 $0.00
10 mg $192.00 $0.00
50 mg $840.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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