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MK 886 (sodium salt)

Cayman Chemical Item Number 10133

(CAS 118427-55-7)

MK 886 (sodium salt) (CAS 118427-55-7)

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Description

Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO).1 The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active.2 MK 886 binds to FLAP with high-affinity and prevents 5-LO activation. MK 886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM.3 In human whole blood, leukotriene biosynthesis is inhibited by MK 886 with an IC50 of 1.1 µM.

1 Ford-Hutchinson, A.W., Gresser, M., and Young, R.N. 5-Lipoxygenase. Annu Rev Biochem 63 383-417 (1994).

2 Abramovitz, M., Wong, E., Cox, M.E., et al. 5-Lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. Eur J Biochem 215 105-111 (1993).

3 Dixon, R.A.F., Diehl, R.E., Opas, E., et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 282-284 (1990).

Formal Name 1-​[(4-​chlorophenyl)methyl]-​3-​[(1,​1-​dimethylethyl)thio]-​α,​α-​dimethyl-​5-​(1-​methylethyl)-​1H-​indole-​2-​propanoic acid,​ sodium salt
CAS Number 118427-55-7
Molecular Formula C27H33ClNO2S · Na
Formula Weight 494.1
Formulation A crystalline solid
Purity >99%
λmax 226, 289 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​(C([O-]​)​=O)​CC1=C(SC(C)​(C)​C)​C2=CC(C(C)​C)​=CC=C2N1CC3=CC=C(Cl)​C=C3.[Na+]​

Background Reading

Ford-Hutchinson, A.W., Gresser, M., and Young, R.N. 5-Lipoxygenase. Annu Rev Biochem 63 383-417 (1994).

. . Can J Physiol Pharmacol 67 456 (1989).

Dixon, R.A.F., Diehl, R.E., Opas, E., et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 282-284 (1990).

Abramovitz, M., Wong, E., Cox, M.E., et al. 5-Lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. Eur J Biochem 215 105-111 (1993).

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MK 886 (sodium salt) is available in the following screening library:

Size Price Quantity Subtotal
1 mg $15.00 $0.00
5 mg $68.00 $0.00
10 mg $120.00 $0.00
25 mg $263.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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