See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

MK 886 (sodium salt)

Cayman Chemical Item Number 10133

(CAS 118427-55-7)

MK 886 (sodium salt) (CAS 118427-55-7)

See more

Description

Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO).1 The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active.2 MK 886 binds to FLAP with high-affinity and prevents 5-LO activation. MK 886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM.3 In human whole blood, leukotriene biosynthesis is inhibited by MK 886 with an IC50 of 1.1 µM.

1 Ford-Hutchinson, A.W., Gresser, M., and Young, R.N. 5-Lipoxygenase. Annu Rev Biochem 63 383-417 (1994).

2 Abramovitz, M., Wong, E., Cox, M.E., et al. 5-Lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. Eur J Biochem 215 105-111 (1993).

3 Dixon, R.A.F., Diehl, R.E., Opas, E., et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 282-284 (1990).

Formal Name 1-​[(4-​chlorophenyl)methyl]-​3-​[(1,​1-​dimethylethyl)thio]-​α,​α-​dimethyl-​5-​(1-​methylethyl)-​1H-​indole-​2-​propanoic acid,​ sodium salt
CAS Number 118427-55-7
Molecular Formula C27H33ClNO2S · Na
Formula Weight 494.1
Formulation A crystalline solid
Purity >99%
λmax 226, 289 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CC(C)​(C([O-]​)​=O)​CC1=C(SC(C)​(C)​C)​C2=CC(C(C)​C)​=CC=C2N1CC3=CC=C(Cl)​C=C3.[Na+]​

Background Reading

Ford-Hutchinson, A.W., Gresser, M., and Young, R.N. 5-Lipoxygenase. Annu Rev Biochem 63 383-417 (1994).

. . Can J Physiol Pharmacol 67 456 (1989).

Dixon, R.A.F., Diehl, R.E., Opas, E., et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343 282-284 (1990).

Abramovitz, M., Wong, E., Cox, M.E., et al. 5-Lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. Eur J Biochem 215 105-111 (1993).

Show all 4 Hide all but first 3

MK 886 (sodium salt) is available in the following screening library:

Size Price Quantity Subtotal
1 mg $15.00 $0.00
5 mg $68.00 $0.00
10 mg $120.00 $0.00
25 mg $263.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

5-Lipoxygenase (human recombinant)
5-Lipoxygenase Polyclonal Antibody
5-Lipoxygenase (potato)
HZ52 New
Show all 4 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?