Cayman Chemical | HQL-79 | Description (CAS 162641-16-9)

10134 HQL-79

(CAS 162641-16-9)

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• See more Inhibitors; Allergy/Asthma

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HQL-79 is a selective inhibitor of hematopoietic prostaglandin D (PGD) synthase. Structurally, it is a synthetic tetrazole compound originally prepared as a possible antihistamine.¹ Subsequent evaluation in models of allergy and asthma demonstrates the HQL-79 is orally available, and inhibits the synthesis of PGD₂.² HQL-79 is thus a likely lead compound for the preparation of potent, selective hematopoietic PGD synthase inhibitors.

1 Matsushita, K., Nobutoshi, A., Aritake, K. Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. Jpn J Pharmacol 78(1) 11-22 (1998).

2 Matsushita, K., Nobutoshi, A., Hizue, A. Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models. Jpn J Pharmacol 78(1) 1-10 (1998).

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Pricing updated 2010-03-14.
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