See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

HQL-79

Cayman Chemical Item Number 10134

(CAS 162641-16-9)

HQL-79 (CAS 162641-16-9)

See more

Description

HQL-79 is a selective inhibitor of hematopoietic prostaglandin D (PGD) synthase. Structurally, it is a synthetic tetrazole compound originally prepared as a possible antihistamine.1 Subsequent evaluation in models of allergy and asthma demonstrates the HQL-79 is orally available, and inhibits the synthesis of PGD2.2 HQL-79 is thus a likely lead compound for the preparation of potent, selective hematopoietic PGD synthase inhibitors.

1 Matsushita, K., Nobutoshi, A., and Aritake, K. Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. Jpn J Pharmacol 78(1) 11-22 (1998).

2 Matsushita, K., Nobutoshi, A., and Hizue, A. Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models.. Jpn J Pharmacol 78(1) 1-10 (1998).

Formal Name 4-​(diphenylmethoxy)-​1-​[3-​(1H-​tetrazol-​5-​yl)propyl-​piperidine
CAS Number 162641-16-9
Molecular Formula C22H27N5O
Formula Weight 377.5
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
c1ccc(cc1)​C(OC1CCN(CCCc2nnn[nH]​2)​CC1)​c1ccccc1

Background Reading

Matsushita, K., Nobutoshi, A., and Hizue, A. Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models.. Jpn J Pharmacol 78(1) 1-10 (1998).

Matsushita, K., Nobutoshi, A., and Aritake, K. Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. Jpn J Pharmacol 78(1) 11-22 (1998).

HQL-79 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $28.00 $0.00
5 mg $126.00 $0.00
10 mg $224.00 $0.00
100 mg $1,680.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Prostaglandin D2
Prostaglandin D2-MOX EIA Kit
Prostaglandin D2-MOX Express EIA Kit
Prostaglandin D Synthase (hematopoietic-type) Polyclonal Antibody
Prostaglandin D Synthase (lipocalin-type) Polyclonal Antibody
Prostaglandin E2 Express EIA Kit
Show all 6 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?