Cayman Chemical | GPR17 (C-Term) Polyclonal Antibody | Description • G Protein-Coupled Receptor 17

10136 GPR17 (C-Term) Polyclonal Antibody

G Protein-Coupled Receptor 17

• See more Flow Cytometry; Immunocytochemistry; Western Blot; Antibodies; Apoptosis; Cell Biology; Hypoxia; Obesity; Vascular Disease

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Antigen: human GPR17 amino acids 351-367 (SFEGKTNESSLSAKSEL) · Host: rabbit · Peptide sequence: WB, FC, and ICC · GPR17 is a G protein-coupled receptor that has been identified as a dualistic receptor recognizing signals from two unrelated chemical families: nucleotides and CysLTs. These endogenous signaling molecules increase in concentration during organ injury to alert surrounding cells to the damage and begin repair.^1,2 The deorphanization of GPR17 supports the suggested crosstalk between nucleotides and CysLTs during inflammation and injury. mRNA transcripts encoding this transmembrane receptor are most strongly expressed in the brain, kidney, and heart. Upon ischemic injury, GPR17 is upregulated in these tissues and its inhibition has been shown to decrease ischemic damage. This finding suggests GPR17 as a pharmacological target of ischemic injury.³ Cayman’s peptide affinity-purified polyclonal antibody recognizes the C-terminal region of human GPR17. This protein exists in two isoforms, differing by 28 amino acids at the receptor N-terminus. The longer form of the protein consists of 367 amino acids with a calculated molecular weight of 41kDa. The human and rat proteins share 89 % amino acid identity.³ Post-translational modifications may explain the observed SDS-PAGE gel-migration to 57 kDa on immunoblot.

1 Lecca, D., Trincavelli, M.L., Gelosa, P., et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One (2008).

2 Parravicini, C., Ranghino, G., Abbracchio, M.P., et al. GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. BMC Bioinformatics (2008).

3 Ciana, P., Fumagalli, M., Trincavelli, M.L., et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J 25 4615-4627 (2006).

	Download Product Insert 142 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 10136 GPR17 (C-Term) Polyclonal Antibody

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.

Related Products

Your shopping cart is empty.

ordered by catalog number

·	GPR17 (C-Term) Polyclonal Antibody
·	Methyl Arachidonyl Fluorophosphonate
·	Testosterone EIA Kit
·	Tryptophan Hydroxylase (Phospho-Ser260) Polyclonal Antibody

Do you have any new product ideas?