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Icilin

Cayman Chemical Item Number 10137

AG 3-5 (CAS 36945-98-9)

Icilin (CAS 36945-98-9)

See more	Receptor Biochemistry (344) Receptor Agonist (161) Neuroscience (725)

Description

Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat); TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin (AG 3-5) is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol.¹ Icilin induces sensations of intense cold when applied orally in humans, and induces 'wet dog shakes', a behavioral marker of cold sensation, when given to rats. Icilin should serve as the reference cold nociceptive agonist for TRP-type ion channels in the future.²

1 McKemy, D.D., Neuhausser, W.M., and Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52-58 (2002).

2 Wei, E.T., and Seid, D.A. AG-3-5: A chemical producing sensations of cold. J Pharm Pharmacol 35 110-112 (1983).

Synonyms	AG 3-5
Formal Name	3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
CAS Number	36945-98-9
Molecular Formula	C₁₆H₁₃N₃O₄
Formula Weight	311.3
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1N([H])C(C2=CC([N+]([O-])=O)=CC=C2)=CCN1C3=CC=CC=C3O

Background Reading

McKemy, D.D., Neuhausser, W.M., and Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52-58 (2002).

Podesva, C., and Do Nascimento, J.M. 1,2,3,6-Tetrahydropyrimidine-2-one compounds and processes for making them. 66,872 1-28 (1974).

Wei, E.T., and Seid, D.A. AG-3-5: A chemical producing sensations of cold. J Pharm Pharmacol 35 110-112 (1983).

Icilin is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$8.00		$0.00
5 mg	$36.00		$0.00
10 mg	$64.00		$0.00
50 mg	$280.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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