15-deoxy-Δ12,14-Prostaglandin J2-biotin

15-deoxy-Δ^12,14-Prostaglandin J₂-biotin

Cayman Chemical Item Number 10141

15-deoxy-Δ^12,14-PGJ₂-biotin

Description

15-deoxy-Δ^12,14-Prostaglandin J₂ (15-deoxy-Δ^12,14-PGJ₂) is one of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.^1,2,3 The activity of the compounds in this class, which includes PGs in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G protein-coupled receptor) pathways. 15-deoxy-Δ^12,14-PGJ₂-biotin is an affinity probe which allows 15-deoxy-Δ^12,14-PGJ₂ to be detected through an interaction with the biotin ligand. 15-deoxy-Δ^12,14-PGJ₂-biotin was designed to allow 15-deoxy-Δ^12,14-PGJ₂ to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs.

1 Krakoff, L.R., Vlachakis, N., Mendlowitz, M., et al. Differential effect of prostaglandin A₁ in hypertensive patients with low, normal and high renin. Clin Sci Mol Med 48 311s-313s (1975).

2 Kikuchi, Y., Kita, T., Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metastasis Rev 13 309-315 (1994).

3 Mueller, E., Drori, S., Aiyer, A., et al. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor γ isoforms. J Biol Chem 277(44) 41925-41930 (2002).

Synonyms

15-deoxy-Δ12,14-PGJ2-biotin

Formal Name

N-11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oyl-N’-biotinoyl-1,5-diaminopentane

Molecular Formula

C₃₅H₅₄N₄O₄S

Formula Weight

626.9

Formulation

A solution in ethanol

Purity

>98%

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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O=C1C=C[C@H](C/C=C\CCCC(NCCCCCNC(CCCC[C@@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)/C1=C\C=C\CCCCC

Background Reading

Krakoff, L.R., Vlachakis, N., Mendlowitz, M., et al. Differential effect of prostaglandin A₁ in hypertensive patients with low, normal and high renin. Clin Sci Mol Med 48 311s-313s (1975).

Mueller, E., Drori, S., Aiyer, A., et al. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor γ isoforms. J Biol Chem 277(44) 41925-41930 (2002).

Kikuchi, Y., Kita, T., Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metastasis Rev 13 309-315 (1994).

15-deoxy-Δ12,14-Prostaglandin J2-biotin is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size

Price

Quantity

Subtotal

50 µg 
$96.00

$0.00

100 µg 
$182.00

$0.00

500 µg 
$768.00

$0.00

1 mg 
$1,344.00

$0.00

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15-deoxy-Δ^12,14-Prostaglandin J₂-biotin