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BM 567

Cayman Chemical Item Number 10155

(CAS 284464-77-3)

BM 567 (CAS 284464-77-3)

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Sold and made under non-exclusive license from Université of Liège.

Description

Thromboxane A2 (TXA2) is a potent thrombogenic and vasoconstrictor eicosanoid, produced in large quantities by activated platelets. TXA2 has been implicated as a causal factor in the onset of stroke and myocardial infarction. BM 567 is a dual acting antithrombogenic agent, acting as an inhibitor of TXA2 synthase and as an antagonist of the TP receptor, the G protein-coupled receptor mediating TXA2 activity in platelets and vascular smooth muscle. BM 567 antagonizes the vascular smooth muscle TP receptor with an IC50 value of 1.1 nM. It inhibits platelet TX synthase with an IC50 value of 12 nM.1

1 Michaux, C., Rolin, S., Dogné, J., et al. Structure determination and comparison of BM567, a sulfonylurea, with Terbogrel, two compounds with dual action, thromboxane receptor antagonism, and thromboxane synthase inhibition. Bioorg Med Chem Lett 11 1019-1022 (2001).

Formal Name 2-​(cyclohexylamino)-​5-​nitro-​N-​[(pentylamino)carbonyl]-​benzenesulfonamide
CAS Number 284464-77-3
Molecular Formula C18H28N4O5S
Formula Weight 412.5
Formulation A crystalline solid
Purity >98%
λmax 212, 365 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCNC(=O)​NS(=O)​(=O)​c1cc(ccc1NC1CCCCC1)​[N]​(=O)​O

Background Reading

Michaux, C., Rolin, S., Dogné, J., et al. Structure determination and comparison of BM567, a sulfonylurea, with Terbogrel, two compounds with dual action, thromboxane receptor antagonism, and thromboxane synthase inhibition. Bioorg Med Chem Lett 11 1019-1022 (2001).

BM 567 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
50 mg $1,610.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Sold and made under non-exclusive license from Université of Liège.

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