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BAY-u3405

Cayman Chemical Item Number 10156

Ramatroban (CAS 116649-85-5)

BAY-u3405 (CAS 116649-85-5)

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Description

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G-protein coupled receptors, designated DP1 and DP2/CRTH2. BAY-u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of the thromboxane receptor (TP receptor).1 BAY-u3405 is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM.2 BAY-u3405 is more potent at the DP2 receptor than the TP receptor by 4-5 fold. BAY-u3405 is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.

1 McKenniff, M.G., Norman, P., Cuthbert, N.J., et al. BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro.. Br J Pharmacol 104(3) 585-590 (1991).

2 Sugimoto, H., Shichijo, M., Iino, T., et al. An orally bioavailable small molecule antagonist of CRTH2, Ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther 305 347-352 (2003).

Synonyms
  • Ramatroban
Formal Name 3R-​[[(4-​fluorophenyl)sulfonyl]amino]-​1,​2,​3,​4-​tetrahydro-​9H-​carbazole-​9-​propanoic acid
CAS Number 116649-85-5
Molecular Formula C21H21FN2O4S
Formula Weight 416.5
Formulation A crystalline solid
Purity >98%
λmax 228, 285 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=S(N[C@H]​(CC1)​CC2=C1N(CCC(O)​=O)​C3=CC=CC=C23)​(C4=CC=C(F)​C=C4)​=O

Background Reading

McKenniff, M.G., Norman, P., Cuthbert, N.J., et al. BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro.. Br J Pharmacol 104(3) 585-590 (1991).

Sugimoto, H., Shichijo, M., Iino, T., et al. An orally bioavailable small molecule antagonist of CRTH2, Ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther 305 347-352 (2003).

BAY-u3405 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $17.00 $0.00
5 mg $77.00 $0.00
10 mg $136.00 $0.00
50 mg $595.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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