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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Treprostinil

Cayman Chemical Item Number 10162

Remodulin® (CAS 81846-19-7)

Treprostinil (CAS 81846-19-7)

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Description

Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin that is used clinically for the treatment of PPH under the trade name Remodulin®. The structural modifications in treprostinil compared to prostacyclin increase the plasma half-life from 2 minutes to 34 and 85 minutes for intravenous and subcutaneous infusion of the drug, respectively.1 In addition to treprostinil’s direct vasodilatory effects, it also inhibits inflammatory cytokine (TNFα, IL-1β, IL-6, GM-CF) production by human alveolar macrophages in the sub-micromolar range by preventing NF-κB translocation to the nucleus.2

1 Olschewski, H., Rose, F., Schermuly, R., et al. Prostacyclin and its analogues in the treatment of pulmonary hypertension. Pharmacol Ther 102 139-153 (2004).

2 Raychauduri, B., Malur, A., Bonfield, T.L., et al. The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages. J Biol Chem 277(36) 33344-33348 (2002).

Synonyms
  • Remodulin®
Formal Name [[(1R,​2R,​3aS,​9aS)-​2,​3,​4,​9,​9a-​hexahydro-​2-​hydroxy-​1-​[(3S)-​3-​hydroxyoctyl]-​1H-​benz[f]inden-​5-​yl]oxy]acetic acid
CAS Number 81846-19-7
Molecular Formula C23H34O5
Formula Weight 390.5
Formulation A crystalline solid
Purity >98%
λmax 206, 218, 277 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C(O)​COC1=C(C[C@]​(C[C@@H]​(O)​[C@@H]​2CC[C@@H]​(O)​CCCCC)​([H]​)​[C@]​2([H]​)​C3)​C3=CC=C1

Background Reading

Olschewski, H., Rose, F., Schermuly, R., et al. Prostacyclin and its analogues in the treatment of pulmonary hypertension. Pharmacol Ther 102 139-153 (2004).

Raychauduri, B., Malur, A., Bonfield, T.L., et al. The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages. J Biol Chem 277(36) 33344-33348 (2002).

Treprostinil is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $79.00 $0.00
5 mg $356.00 $0.00
10 mg $632.00 $0.00
50 mg $2,765.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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