101640  DP1 Receptor Polyclonal Antibody

Prostaglandin D2 Receptor 1; PGD2 Receptor 1

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• See more Immunocytochemistry; Western Blot; Antibodies; Allergy/Asthma; Atherosclerosis; Inflammation

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Antigen: murine DP1 receptor N-terminal amino acids 2-21 · Host: rabbit · Application(s): WB and ICC; other applications not tested · The DP1 receptor is one of two receptor isoforms for prostaglandin D2 (PGD2), a major cyclooxygenase metabolite of arachidonic acid. As a G-protein coupled receptor (GPCR), the receptor primarily couples to Gs to increase cAMP, but also transiently increases Ca2+, apparently through the cAMP pathway.1 DP1 receptor mRNA has been detected in various tissues and cells including brain, spleen, lung, bone marrow, stomach, skin, and mast cells,2,3,4 however little is know about its protein localization due to its low level of expression. Cayman’s DP1 receptor polyclonal antibody detects the protein by western blot in samples such as cerebral cortex, hippocampus, and HT-29 cells, a colorectal cancer cell line shown to express this receptor.5 The antibody can also be used in immunocytochemistry/immunohistochemistry to detect DP1 receptor expression in cells and tissues.
1  Kabashima, K., Narumiya, S. The DP receptor, allergic inflammation and asthma. Prostaglandins Leukot Essent Fatty Acids 69 187-194 (2003).
2  Hirata, M., Kakizuka, A., Aizawa, M., et al. Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc Natl Acad Sci USA 91 11192-11196 (1994).
3  missing reference text
4  Narumiya, S., Sugimoto, Y., Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79 1193-1226 (1999).
5  Hawcroft, G., Gardner, S.H., Hull, M.A. Expression of prostaglandin D2 receptors DP1 and DP2 by human colorectal cancer cells. Cancer Lett 210 81-84 (2004).


Purchase 101640 DP1 Receptor Polyclonal Antibody

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.

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