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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

BEC

Cayman Chemical Item Number 10170

(CAS 63107-40-4)

BEC (CAS 63107-40-4)

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Description

L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 µM.1 It is also a potent inhibitor of human arginase II with Ki values of 0.31 µM and 30 nM at pH 7.5 and 9.5, respectively.2 It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM.1

1 Kim, N.N., Cox, J.D., Baggio, R.F., et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry 40 2678-2688 (2001).

2 Colleluori, D.M., and Ash, D.E. Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356-9362 (2001).

Formal Name S-​(2-​boronoethyl)-​L-​cysteine
CAS Number 63107-40-4
Molecular Formula C5H12BNO4S
Formula Weight 193.0
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OB(O)​CCSCC(N)​C(=O)​O

Background Reading

Kim, N.N., Cox, J.D., Baggio, R.F., et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry 40 2678-2688 (2001).

Colleluori, D.M., and Ash, D.E. Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356-9362 (2001).

BEC is available in the following screening library:

Size Price Quantity Subtotal
1 mg $27.00 $0.00
5 mg $122.00 $0.00
10 mg $216.00 $0.00
25 mg $473.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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TRIM
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