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FP Receptor Polyclonal Antibody

Cayman Chemical Item Number 101802

Prostaglandin F2α Receptor; PGF2α Receptor

FP Receptor Polyclonal Antibody

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Description

Antigen: mouse FP receptor amino acids 2-16 (SMNSSKQPVSPAAGL) · Host: rabbit · Application(s): WB · The prostaglandin F2α receptor (FP receptor) is a G protein-coupled receptor known to elicit smooth muscle contraction in a variety of tissues.1 FP receptor mRNA is found in reproductive, gastric, neural, and ocular tissues as well as specialized cells of the kidney.2,3,4,5 Two FP receptor isoforms, FPA and FPB have been identified in sheep.6 FPB receptor is truncated at the carboxy-terminus thereby preventing desensitization (which normally occurs by protein kinase C phosphorylation of FPA) and produces aberrant signalling in FPB transfectants.7,8 The existence of a truncated human FP isoform responsible for signal-amplification contributing to luteolysis, cell growth, or malignant transformation is currently unknown.6,7,8,9

1 Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79 1193-1226 (1999).

2 Abramovitz, M., Boie, Y., Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem 269 2632-2636 (1994).

3 Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett 355 317-325 (1994).

4 Kitanaka, J., Hasimoto, H., Sugimoto, Y., et al. Cloning and expression of a cDNA for rat prostaglandin F2α receptor. Prostaglandins 48 31-41 (1994).

5 Mukhopadhyay, P., Bian, L., Yin, H., et al. Localization of EP1 and FP receptors in human ocular tissues by in situ hybridization. Invest Ophthamol Vis Sci 42(2) 424-428 (2001).

6 Pierce, K.L., Bailey, T.J., Hoyer, P.B., et al. Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor. J Biol Chem 272 883-887 (1997).

7 Fujino, H., Srinivasan, D., Pierce, K.L., et al. Differential regulation of prostaglandin F2α receptor isoforms by protein kinase C. Mol Pharmacol 57 353-358 (2000).

8 Fujino, H., and Regan, J.W. FP prostanoid receptor activation of a T-cell factor/β-catenin signaling pathway. J Biol Chem 276(16) 12489-12492 (2001).

9 Sugimoto, Y., Yamasaki, A., Segi, E., et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science 277 681-683 (1997).

Synonyms
  • Prostaglandin F2α Receptor
  • PGF2α Receptor
Formulation 250 µg peptide affinity-purified IgG in 500 µl TBS, pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett 355 317-325 (1994).

Mukhopadhyay, P., Bian, L., Yin, H., et al. Localization of EP1 and FP receptors in human ocular tissues by in situ hybridization. Invest Ophthamol Vis Sci 42(2) 424-428 (2001).

Fujino, H., and Regan, J.W. FP prostanoid receptor activation of a T-cell factor/β-catenin signaling pathway. J Biol Chem 276(16) 12489-12492 (2001).

Fujino, H., Srinivasan, D., Pierce, K.L., et al. Differential regulation of prostaglandin F2α receptor isoforms by protein kinase C. Mol Pharmacol 57 353-358 (2000).

Abramovitz, M., Boie, Y., Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem 269 2632-2636 (1994).

Sugimoto, Y., Hasumoto, K., Namba, T., et al. Cloning and expression of cDNA for mouse prostaglandin F receptor. J Biol Chem 269 1356-1360 (1994).

Pierce, K.L., Bailey, T.J., Hoyer, P.B., et al. Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor. J Biol Chem 272 883-887 (1997).

Narumiya, S., Sugimoto, Y., and Ushikubi, F. Prostanoid receptors: Structures, properties, and functions. Physiol Rev 79 1193-1226 (1999).

Sugimoto, Y., Yamasaki, A., Segi, E., et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science 277 681-683 (1997).

Kitanaka, J., Hasimoto, H., Sugimoto, Y., et al. Cloning and expression of a cDNA for rat prostaglandin F2α receptor. Prostaglandins 48 31-41 (1994).

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Size Price Quantity Subtotal
500 µl $187.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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