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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

COX Inhibitor Pack

Cayman Chemical Item Number 10186

Cyclooxygenase-PAK

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Description

The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype nonselective, irreversible COX inhibitor.1 A series of COX-2 selective inhibitors are available in the COX-PAK, including NS-398, one of the first reported and most widely used.2 Another COX-2-selective inhibitor included is CAY10404, with nearly 500,000-fold COX-2 selectivity.3 The potent COX-1-selective inhibitor SC-560 is an example of a reversible, diaryl heterocycle COX-1 inhibitor with low nM activity.4 Also included is valeroyl salicylate, an irreversible alkylator of COX enzymes with some selectivity toward COX-1.5 Resveratrol is also included in the COX-PAK due to its complex activities, which include COX inhibition, peroxidase inhibition, antioxidant activity, and gene regulation.6,7

1 Vane, J.R., and Botting, R. Inflammation and the mechanism of action of anti-inflammatory drugs. FASEB J 1 89-96 (1987).

2 Futaki, N., Takahashi, S., Yokoyama, M., et al. NS-398, An new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro . Prostaglandins 47 55-59 (1994).

3 Habeeb, A.G., Rao, P.N.P., and Knaus, E.E. Design and syntheses of diarylisoxazoles: Novel inhibitors of cyclooxygenase-2 (COX-2) with analgesic-antiinflammatory activity. Drug Dev Res 51 273-286 (2000).

4 Smith, C.J., Zhang, Y., Koboldt, C.M., et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci USA 95 13313-13318 (1998).

5 Bhattacharyya, D.K., Lecomte, M., Dunn, J., et al. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Arch Biochem Biophys 317 19-24 (1995).

6 Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

7 Jang, M., Cai, L., Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 218-220 (1997).

Synonyms
  • Cyclooxygenase-PAK
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Vane, J.R., and Botting, R. Inflammation and the mechanism of action of anti-inflammatory drugs. FASEB J 1 89-96 (1987).

Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).

Jang, M., Cai, L., Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 218-220 (1997).

Bhattacharyya, D.K., Lecomte, M., Dunn, J., et al. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Arch Biochem Biophys 317 19-24 (1995).

Futaki, N., Takahashi, S., Yokoyama, M., et al. NS-398, An new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro . Prostaglandins 47 55-59 (1994).

Gmeiner, P., Kärtner, A., and Junge, D. Practical EPC synthesis of 1,2- and 1,3-amino alcohols. Tetrahedron Lett 34 4325-4326 (1993).

Smith, C.J., Zhang, Y., Koboldt, C.M., et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci USA 95 13313-13318 (1998).

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Size Price Quantity Subtotal
1 ea $508.00 $0.00
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Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Aspirin
CAY10404
NS-398
SC-560
SC-58125
trans-Resveratrol
Valeroyl Salicylate
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