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IDFP

Cayman Chemical Item Number 10215

Isopropyl Dodecylfluorophosphonate (CAS 615250-02-7)

IDFP (CAS 615250-02-7)

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Description

The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB₁) and peripheral cannabinoid (CB₂). Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) hydrolyze 2-AG and AEA, respectively, thus terminating their biological function. IDFP is an organophosphorus compound that dually inhibits MAGL and FAAH with IC₅₀ values of 0.8 and 3 nM, respectively.¹ At 10 mg/kg, IDFP elevates brain levels of 2-AG and AEA more than 10-fold, and decreases levels of arachidonic acid by a similar magnitude.¹

1 Nomura, D.K., Blankman, J.L., Simon, G.M., et al. Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol 4(6) 373-378 (2008).

Synonyms	Isopropyl Dodecylfluorophosphonate
Formal Name	P-dodecyl-1-methylethyl ester-phosphonofluoridic acid
CAS Number	615250-02-7
Molecular Formula	C₁₅H₃₂FO₂P
Formula Weight	294.4
Formulation	A solution in methyl acetate
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCCCCCCP(=O)(F)OC(C)C

Background Reading

Nomura, D.K., Blankman, J.L., Simon, G.M., et al. Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol 4(6) 373-378 (2008).

IDFP is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
500 µg	$39.00		$0.00
1 mg	$74.00		$0.00
5 mg	$312.00		$0.00
10 mg	$546.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Related Products

Methyl Arachidonyl Fluorophosphonate

Methyl α-Linolenyl Fluorophosphonate

Methyl γ-Linolenyl Fluorophosphonate

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