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10221 Phosphothreonine (Ascites) Monoclonal Antibody (Clone 18F6)
Phosphothreonine (Ascites) Monoclonal Antibody (Clone 18F6) Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Clone designation:
18F6
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Host:
Mouse
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Isotype:
IgG1κ
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Application(s):
ELISA, WB
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Protein phosphorylation is an important post-translational modification that serves many key functions to regulate a protein’s activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time.1 Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation, and neurological disorders.2,3,4
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1
Goto, H., Kiyono, T., Tomono, Y., et al. Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nature Cell Biology 8 180-187 (2005).
2
Blume-Jensen, P., Hunter, T. Oncogenic kinase signalling. Nature 411 355-365 (2001).
3
Downward, J. The ins and outs of signalling. Nature 411 759-762 (2001).
4
Pawson, T., Saxton, T.M. Signaling networks - Do all roads lead to the same genes?. Cell 97 675-678 (1999).
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Purchase 10221 Phosphothreonine (Ascites) Monoclonal Antibody (Clone 18F6)
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
Please contact our
Sales Department
for a quote or to purchase.
Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services.
To ask for assistance with one of our products please contact our Technical Help staff.
Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-13.
Prices are subject to change without notice.
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