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β-Amyloid (1-8, A2V) Peptide Exclusive

Cayman Chemical Item Number 10229

Aβ; β-amyloid (1-8) dominant negative; Aβ 1-8 mutant

See more	Peptides (10) Alzheimer's Research (48)

Description

β-Amyloid peptide (1-42) aggregation results in the formation of neurotoxic fibrils or globular oligomers.¹ The amyloid precursor protein (APP) mutation Ala673Val results in disease for homozygous carriers but not for heterozygous carriers. The mutation generates β-Amyloid peptide with valine at amino acid position two. Biochemical analysis of Aβ (1-42) aggregation suggests this small peptide may be a useful guide for developing β-amyloid peptide aggregation inhibitors.²

1 Wolfe, M.S. Therapeutic strategies for Alzheimer’s disease. Nat Rev Drug Discov 1 859-866 (2002).

2 Di Fede, G., Catania, M., Morbin, M., et al. A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 323 1473-1477 (2009).

Synonyms	Aβ β-amyloid (1-8) dominant negative Aβ 1-8 mutant
Formula Weight	1004.0
Formulation	1 mg of lyophilized peptide
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Kanekiyo, T., Ban, T., Aritake, K., et al. Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid. Proc Natl Acad Sci USA 104(15) 6412-6417 (2007).

Di Fede, G., Catania, M., Morbin, M., et al. A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science 323 1473-1477 (2009).

Wolfe, M.S. Therapeutic strategies for Alzheimer’s disease. Nat Rev Drug Discov 1 859-866 (2002).

Size	Price	Quantity	Subtotal
1 ea	$61.00		$0.00
Bulk	Contact
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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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