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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

8-iso Prostaglandin A2

Cayman Chemical Item Number 10235

8-iso Prostaglandin A2

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Description

Isoprostanes are prostaglandin (PG)-like compounds produced in vivo by free radical-catalyzed peroxidation of arachidonoyl-containing lipids. 8-iso PGA2 is one of several isoprostanes produced from peroxidation of arachidonic acid esterified in phospholipids.1 8-iso PGA2 is the dehydration product of 8-iso PGE2, a potent renal vasoconstrictor.2 Evidence for the in vivo production of 8-iso PGA2 has been shown in rat liver under conditions of oxidative stress.3 There are no published studies of the pharmacological properties of 8-iso PGA2.

1 Morrow, J.D., Minton, T.A., Mukundan, C.R., et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem 269 4317-4326 (1994).

2 Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).

3 Chen, Y., Zackert, W.E., Robers, L.J.I., et al. Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-isoprostane (8-iso-prostaglandin A2) in vivo. Biochem Biophys Acta 1436 550-556 (1999).

Formal Name 9-​oxo-​15S-​hydroxy-​(8β)-​prosta-​5Z,​10,​13E-​trien-​1-​oic acid
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in methyl acetate
Purity >98%
λmax 217 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1[C@@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​C=C1

Background Reading

Chen, Y., Zackert, W.E., Robers, L.J.I., et al. Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-isoprostane (8-iso-prostaglandin A2) in vivo. Biochem Biophys Acta 1436 550-556 (1999).

Morrow, J.D., Minton, T.A., Mukundan, C.R., et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem 269 4317-4326 (1994).

Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).

8-iso Prostaglandin A2 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $76.00 $0.00
5 mg $342.00 $0.00
10 mg $608.00 $0.00
50 mg $2,660.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-09. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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