10235  8-iso Prostaglandin A2
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• See more Isoprostanes; Prostaglandins; Oxidative Injury

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Isoprostanes are prostaglandin (PG)-like compounds produced in vivo by free radical-catalyzed peroxidation of arachidonoyl-containing lipids. 8-iso PGA2 is one of several isoprostanes produced from peroxidation of arachidonic acid esterified in phospholipids.1 8-iso PGA2 is the dehydration product of 8-iso PGE2, a potent renal vasoconstrictor.2 Evidence for the in vivo production of 8-iso PGA2 has been shown in rat liver under conditions of oxidative stress.3 There are no published studies of the pharmacological properties of 8-iso PGA2.
1  Morrow, J.D., Minton, T.A., Mukundan, C.R., et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem 269 4317-4326 (1994).
2  Longmire, A.W., Roberts, L.J., Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).
3  Chen, Y., Zackert, W.E., Robers, L.J.I., et al. Evidence for the formation of a novel cyclopentenone isoprostane, 15-A2t-isoprostane (8-iso-prostaglandin A2) in vivo. Biochem Biophys Acta 1436 550-556 (1999).


Purchase 10235 8-iso Prostaglandin A2

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-16.
Prices are subject to change without notice.

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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