11β-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide

Cayman Chemical Item Number 10242

11β-HSD2

Description

Application(s): WB · 11-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11β-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.¹ Expression of 11β-HSD2 mRNA and protein has been shown in placenta and mineralocorticoid target tissues, particularly the kidney.² In mouse, expression of this enzyme is tissue- and developmentally specific, indicating the importance of the enzyme in regulating glucocorticoid-mediated maturation.³ Cayman’s 11β-HSD2 polyclonal antibody detects a band at around 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.

1 Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 88(6) 2384-2392 (2003).

2 White, P.C., Mune, T., and Agarwal, A.K. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 18(1) 135-156 (1997).

3 Thompson, A., Han, V.K.M., and Yang, K. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. J Steroid Biochem Mol Biol 88 367-375 (2004).

Synonyms

11β-HSD2

Formulation

200 µg of peptide in 200 µl of TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

White, P.C., Mune, T., and Agarwal, A.K. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 18(1) 135-156 (1997).

Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 88(6) 2384-2392 (2003).

Thompson, A., Han, V.K.M., and Yang, K. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. J Steroid Biochem Mol Biol 88 367-375 (2004).

Size

Price

Quantity

Subtotal

200 µg

$107.00

$0.00

Bulk

Contact

Cart Total

$0.00