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13,14-dihydro-15-keto Prostaglandin A₂

Cayman Chemical Item Number 10260

13,14-dihydro-15-keto PGA₂ (CAS 74872-89-2)

13,14-dihydro-15-keto Prostaglandin A2 (CAS 74872-89-2)

See more	Prostaglandins (513)

Description

PGE₂ is metabolized rapidly to 13,14-dihydro-15-keto PGE₂, which is present in the plasma of humans and other mammals. 13,14-dihydro-15-keto PGA₂ results from the non-enzymatic dehydration of 13,14-dihydro-15-keto PGE₂, a process which is accelerated by the presence of albumin.^1,2 Further decomposition of 13,14-dihydro-15-keto PGA₂ by the intentional addition of base produces bicyclo PGE₂, a stable marker of PGE₂ biosynthesis.²

1 Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE₂: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

2 Fitzpatrick, F.A., Aguirre, R., Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE₂. Prostaglandins 19 917-931 (1980).

Synonyms	13,14-dihydro-15-keto PGA2
Formal Name	9,15-dioxo-prosta-5Z,10-dien-1-oic acid
CAS Number	74872-89-2
Molecular Formula	C₂₀H₃₀O₄
Formula Weight	334.5
Formulation	A solution in methyl acetate
Purity	>98%
λ_max	216 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CCCCC)=O)C=C1

Background Reading

Fitzpatrick, F.A., Aguirre, R., Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE₂. Prostaglandins 19 917-931 (1980).

Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE₂: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

Peskar, B.M., Günter, B., Steffens, C., et al. Antibodies against dehydration products of 15-keto-13,14-dihydro-prostaglandin E₂. FEBS Lett 115 123-126 (1980).

Bothwell, W., Verburg, M., Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E₁ and E₂: An indirect index of their in vivo disposition and pharmacokinetics. J Pharmacol Exp Ther 220 229-235 (1982).

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13,14-dihydro-15-keto Prostaglandin A2 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$64.00		$0.00
5 mg	$288.00		$0.00
10 mg	$512.00		$0.00
50 mg	$2,240.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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13,14-dihydro-15-keto Prostaglandin A2