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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Histone H4 (human recombinant)

Cayman Chemical Item Number 10264

H4; Histone H4

Histone H4 (human recombinant)

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Description

Peptide sequence: Amino acids 1-103, full-length · Source: recombinant protein, expressed in E. coli · Mr: 11.5 kDa · A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octomer of histones.1 The octamer is composed of two copies of each histone H2A, H2B, H3 and H4. Histones H2A and H2B each form homodimers. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. 2 The N-terminal tail of histone H4 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1

1 Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 14(11) 1008-1016 (2007).

2 Tanaka, Y., Tawaramoto-Sasanuma, M., Kawaguchi, S., et al. Expression and purification of recombinant human histones. Methods 33 3-11 (2004).

Synonyms
  • H4
  • Histone H4
Formulation Lyophilized powder. 50 mM NaPO4 containing 100 mM sodium chloride and 20% glycerol
Purity >95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Size Price Quantity Subtotal
50 µg $25.00 $0.00
100 µg $48.00 $0.00
250 µg $113.00 $0.00
1 mg $350.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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