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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

15-deoxy-Δ12,14-Prostaglandin A2 Exclusive

Cayman Chemical Item Number 10265

15-deoxy-Δ12,14-PGA2 (CAS 112839-31-3)

15-deoxy-Δ12,14-Prostaglandin A2 (CAS 112839-31-3)

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Description

15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ.1,2 Antimitotic and antitumor activity have been reported for a similar analog,3 but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA2 at this time.

1 Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813-819 (1995).

2 Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803-812 (1995).

3 Kato, T., Fukushima, M., Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Res 46 3538-3542 (1986).

Synonyms
  • 15-deoxy-Δ12,14-PGA2
Formal Name 9-​oxo-​prosta-​5Z,​10,​12Z,​14E-​tetraen-​1-​oic acid
CAS Number 112839-31-3
Molecular Formula C20H28O3
Formula Weight 316.5
Formulation A solution in methyl acetate
Purity >98% (isomer mixture)
λmax 324 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1[C@H]​(C/C=C\CCCC(O)​=O)​/C(C=C1)​=C\C=C\CCCCC

Background Reading

Kato, T., Fukushima, M., Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Res 46 3538-3542 (1986).

Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813-819 (1995).

Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803-812 (1995).

Schneider, W.P., Morge, R.A., and Henson, B.E. The occurrence of 13,14-dihydro and 13,14-cis-unsaturated prostaglandins in the coral, Plexaura homomalla. Synthesis of 13,14-cis-prostaglandin E2,15-acetate methyl ester, and the 13,14-cis analogues of prostaglandin F and prostaglandin F. J Am Chem Soc 99 6062-6066 (1977).

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15-deoxy-Δ12,14-Prostaglandin A2 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $56.00 $0.00
1 mg $106.00 $0.00
5 mg $448.00 $0.00
10 mg $784.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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