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10277 ATB-337
ATB-337 Workbook Links
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Hydrogen sulfide (H2S) is a naturally occurring gasotransmitter with vasodilator and inflammatory modulating activity.1,2 Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac.3 In rats, diclofenac at 10-50 µmol/kg caused significant gastrointestinal damage, whereas no damage was observed with ATB-337 treatment at the same dose. ATB-337 at 50 µmol/kg does not promote leukocyte adherence to vascular endothelium, an effect observed with diclofenac treatment alone. COX-1 and COX-2 were inhibited with similar efficacy by diclofenac and ABT-337. An increase in expression of the pro-inflammatory mediator TNF-α, as well as, the adhesion molecules ICAM-1 and LFA-1 were not observed in rats treated with 50 µmol/kg ABT-337, effects seen with equimolar doses of diclofenac. These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.
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1
Li, L., Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air?. Trends Pharmacol Sci 29(2) 84-90 (2007).
2
Wallace, J.L. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends Pharmacol Sci 28(10) 501-505 (2007).
3
Wallace, J.L., Caliendo, G., Santagada, V., et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 132 261-271 (2007).
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Purchase 10277 ATB-337
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-18.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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