10304  NAPE-PLD Blocking Peptide (aa 6-20)
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To be used in conjunction with Cayman’s NAPE-PLD polyclonal antibody (aa 6-20) (Catalog No. 10306) to block protein-antibody complex formation during analysis of NAPE-PLD · N-acylethanolamines (NAEs) are involved in diverse biological processes such as inflammatory regulation, apoptosis, and tissue degeneration.1 In animals, NAEs are mainly biosynthesized via a membrane phospholipid-dependent pathway, which is the enzymatic hydrolysis of N-acyl-phosphatidylethanolamine (NAPE). The enzyme catalyzing this reaction is a phospholipase D subtype selective for NAPE named N-acylphosphatidylethanolamine-hydrolysing phospholipase D (NAPE-PLD). It has been cloned from mouse, rat, and human and is 393-396 amino acids in length, with an estimated molecular weight of 46 kDa. Both NAPE-PLD mRNA and protein activity have been detected in a wide range of tissues with the highest levels in brain, kidney, and testis.2 In rat, NAPE-PLD activity in the brain is low in neonates and is 15-fold higher in adults, whereas the activity remains constant in the heart during development.3
1  Hansen, H.S., Moesgaard, B., Petersen, G., et al. Putative neuroprotective actions of N-acyl-ethanolamines. Pharmacology & Therapeutics 95 119-126 (2002).
2  Okamoto, Y., Morishita, J., Tsuboi, K., et al. Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem 279(7) 5298-5305 (2004).
3  Moesgaard, B., Petersen, G., Jaroszewski, J.W., et al. Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain: A 31P NMR and enzyme activity study. J Lipid Res 41 985-990 (2000 Jan 1).


Purchase 10304 NAPE-PLD Blocking Peptide (aa 6-20)

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-14.
Prices are subject to change without notice.

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