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Prostaglandin A3 Exclusive

Cayman Chemical Item Number 10310

PGA3 (CAS 36614-31-0)

Prostaglandin A3 (CAS 36614-31-0)

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Description

Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles1 and in the ocular tissues of primates.2 Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay.3,4 PGA3 has weak affinity for human PPARγ, with a Ki value of 188 µM.5

1 Lohmus, M., Vahemets, A., Järving, I., et al. Preparative separation of natural prostaglandins E. Preparative Chromatography 1 279-300 (1991).

2 Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J Ocul Pharmacol 3 349-356 (1987).

3 Hibbs, T.A., Lu, B., Smock, S.L., et al. Molecular cloning and charcterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins Other Lipid Mediat 57 133-147 (1999).

4 Castleberry, T.A., Lu, B., Smock, S.L., et al. Molecular cloning and functional charcterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins Other Lipid Mediat 65 167-187 (2001).

5 Ferry, G., Bruneau, V., Beauverger, P., et al. Binding of prostaglandins to human PPARγ: Tool assessment and new natural ligands. Eur J Pharmacol 417 77-89 (2001).

Synonyms
  • PGA3
Formal Name 9-​oxo-​15S-​hydroxy-​prosta-​5Z,​10,​13E,​17Z-​tetraen-​1-​oic acid
CAS Number 36614-31-0
Molecular Formula C20H28O4
Formula Weight 332.4
Formulation A solution in methyl acetate
Purity >98%
λmax 216 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C1[C@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​C/C=C\CC)​C=C1

Background Reading

Lohmus, M., Vahemets, A., Järving, I., et al. Preparative separation of natural prostaglandins E. Preparative Chromatography 1 279-300 (1991).

Ferry, G., Bruneau, V., Beauverger, P., et al. Binding of prostaglandins to human PPARγ: Tool assessment and new natural ligands. Eur J Pharmacol 417 77-89 (2001).

Castleberry, T.A., Lu, B., Smock, S.L., et al. Molecular cloning and functional charcterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins Other Lipid Mediat 65 167-187 (2001).

Hibbs, T.A., Lu, B., Smock, S.L., et al. Molecular cloning and charcterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins Other Lipid Mediat 57 133-147 (1999).

Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J Ocul Pharmacol 3 349-356 (1987).

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Prostaglandin A3 is available in the following screening library:

Size Price Quantity Subtotal
50 µg $85.00 $0.00
100 µg $162.00 $0.00
500 µg $680.00 $0.00
1 mg $1,190.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Eicosapentaenoic Acid
Prostaglandin A2
Prostaglandin E3 Exclusive

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